Microbiome: Gut Bugs and You | Warren Peters | TEDxLaSierraUniversity

Microbiome: Gut Bugs and You | Warren Peters | TEDxLaSierraUniversity


Translator: Rhonda Jacobs
Reviewer: Peter van de Ven When I was just a little boy
when I used the toilet, my mother taught me to wash my hands, and when I flushed
and I looked at what was going down, I’d go, boy, you’d better
wash your hands, you know? And I had this little puppy,
you know, this little dog, and when I saw what came
out of his body, and if I stepped in it, I’d go, boy, I’d better wash my hands. And my mother taught me all about germs
and how bad they were, and you should always
wash your hands, and I believed her. And then I grew up
and I went to medical school, and we had the microscope. And we looked at these bacteria, and we heard these stories
about how they caused these epidemics, and people dying all over the place,
and then antibiotics came aboard, and now we could actually stamp out
these epidemics of these bad germs. And then, all of the sudden,
I started hearing about the good bugs, and I go, “What’s that?” And as we began
to look at the actual genetics, this was the breakthrough that allowed us to actually understand our microbiome, particularly in our GI tract, because when I was just
looking at them through a microscope, it was very limiting. You could only see just certain kinds, but now that we could
actually genetically look at this – this all started about ten years ago,
and many of you are familiar with this – when they started looking
at the genetics of the human, what are the genes? How many genes? What are the genes that we have? Through incredible research,
it became apparent that we actually had, like, 26,000 genes. And I thought, wow, that’s really cool, and everybody was studying the genes
and this was really wonderful, until they started studying
the genes of a rice plant. The rice plant had 46,000 genes. What’s that?! You know, I mean, we’re only 26 … and they’re 46?! And so this was very humbling to say that the rice plant
was more sophisticated than humans. So then about five years ago
everybody got busy, and they started to do
the genome of the bacteria that resides inside of our body. Guess how many genes there are there. 100,000 genes. And so we began to look at,
what are these bugs? Who are these? What are these? So there’s, like, 100 trillion of them. When we think of cells of our body, our biome describes
90 percent of all the cells. We’re only ten percent. So we just heard how wonderful it is
to look at the astronomy and be humbled. I would suggest we probably just need to
look inside of us and really get humble because “the other” is way beyond this. So these genes are incredible –
there’s about 1,000 different varieties, and then when we look
at the species and sort of like that, it’s incredible how diverse this whole environment,
this whole biome is, and just resides in some
just humble you and me. Well, okay, let’s team up with our bugs. So we’re 26,000 and they’re 100,000. Wow, now we can trump the rice plant, (Laughs) so we better stay joined with them. So we begin to do – what actually
does this biome do for us? So we first think of fermentation –
talk about a microbrewery, you know, right here
in our right colon, right here, these bugs are actually fermenting
because this does a lot of good things, and they produce about the equivalent
of a can of beer every day. And, yeah, that’s true.
(Laughs) And so, of course, we handle it
quite nicely and so on, we don’t get tipsy with that much. And so in this process of fermentation, some very important things are created;
they’re called short-chain fatty acids. These short-chain fatty acids
are critical to our immune system. So if you breed a little mouse
that has no biome, this little creature is very vulnerable
to infections and so on. And so in many ways,
this is quite dramatic, and we wonder, where does
this biome come from? Because the little human,
when he’s just inside the uterus, he doesn’t have a lot of bugs – this has been kind of coming
in question here, like, right now – but so far, we’ve always thought of it
being kind of sterile inside there. But when this little child
goes through the birth canal and is breastfed, that is where
the microbiome starts. This is critical
to the life of this child, and our C-section babies
and our babies that don’t get breastfed, this is very difficult, so now, in modern places
and hospitals that understand this, if the little child has to
be born by C-section, a vaginal swab is actually taken
and placed in the child’s face and mouth so that they can actually become
a mirobiome-positive creature, otherwise the immune system
would not develop. So this is very, very vital, so that’s kind of the positive
side of the fermentation. But there’s a negative side to this,
and this is where – remember all these cells, these thousands
of different kinds of bacteria – like most of life, it’s about a balance, and when they are not balanced,
we call it a dysbiosis. When that begins to happen,
we find that it starts causing diseases. You know the word
“irritable bowel syndrome”? Some of you may actually have it – you know, diarrhea,
constipation, abdominal cramps, all these kind of things. You know about colitis,
you’ve heard of people that have colitis. These kinds of things
are when there is a dysbiosis, there’s an imbalance
between the good bugs and the bad bugs. Also, we’re beginning to understand that a lot of the – what is called –
autoimmune diseases, such as rheumatoid arthritis,
multiple sclerosis, these kind of things may indeed be associated with an imbalance
in our microbiome. So another things that our bugs do
is they harvest calories. Now, if you’re starving to death, and you’re having to eat
a lot of grasses and grains, and things that have a lot of fiber, your body can only absorb
a certain number of calories, and we can’t absorb, normally,
any calories from fiber. Fiber just goes down to the biome, and the biome actually
will harvest from the fiber, will actually harvest an extra
10-15 percent of the calories from that food we’ve eaten. This is how humanity has survived
very, very severe circumstances. But just as there’s a positive,
there’s also a negative. And we find when we look at this whole
obese area, people who are overweight – Anybody have any deficit of calories?
Lunch looked pretty good, didn’t it? So we’re not living in a cave anymore
and we’re not starving. So this good thing
can then become a bad thing, particularly if we tend towards
these particular kind of bugs, they’re called Firmicutes –
it’s a big family group – and they harvest extra calories, so when we actually look at the biome
of people who are overweight or people who have diabetes, they tend to have a lot more
of this Firmicutes family. Are you following me? Do you see where this is starting to lead? What if we begin to change the biome to a more balanced biome
for people that were overweight? Ha! You know how
this is going to go, don’t you? And the studies are already
being done in mice, (Laughs) but you know, there’s a lot to this. So this study came out
about two years ago – it was a fascinating study – because they took
these skinny, little mice and they just gave them
an artificial sweetener, and sure enough, the little, skinny mice
became fat and became diabetic. So then the obvious
scientific question is, did the artificial sweetener change
the metabolism of this little mouse, or did it change the microbiome? Guess what? So they did this elegant study – if you think of fecal
transplant as elegant – and they took other little, skinny mice, and they just did a fecal transplant
from the heavy mouse that had diabetes, no artificial sweeteners, and that little, thin mouse became obese,
and overweight, and diabetic. So you begin to see how this science
is beginning to progress. And a third area
that I think is very critical is what we call the gut-brain axis. And when you look at animal studies, you can take, again,
these little germ-free mice, and when they’re born,
they’re kind of autistic. You know, they don’t kind of hang out
with their puppy brothers and sisters, and they don’t eat well,
and they don’t do things well, and they’re kind of autistic. But if you then transplant
normal mouse biome into these little guys, they become normal, they just kind of hang out
with each other and so on. You can see where this
is going, can’t you? (Laughs) And sure enough it’s already happening. So in Europe, there’s some beautiful studies
that are being done on humans. Here in America, there’s some people
that on the side are giving probiotics, you know, probiotics
have the microbiome in them – probiotic enemas – to autistic children,
and actually seeing some development. I have not seen good
randomized controlled trials, but where there’s a little smoke,
there definitely can be some fire. Now in the human studies,
one of the things that we want to know – so we already know
that the gut affects the brain, but we also want to know,
does the brain affect the gut? And sure enough, when we find people
that are under high stress – of course, nobody here in the audience,
I’m sure … high stress … you know … that must be someplace else – but under high stress
the biome actually changes. And what we find
is that there’s a breakdown. So inside the gut there’s
a nice little layer of mucus – so you have all this bacteria
and here you have your gut wall, and then this first layer of mucus,
there is no bacteria, it’s a barrier. The next layer is another layer of mucus
that does have bacteria in it, and under stress, those mucus layers
begin to break down, and antigens from the bacteria
actually penetrate into the muscle wall and therefore into our circulation. So this barrier is broken down. And there’s a great deal of study
that’s going on now to even look at microbiome
and Alzheimer’s. Alzheimer’s is now
being called diabetes type 3, because we know
that those high insulin levels, those high sugar levels,
all these things may well be contributing. So at first I thought,
well, this is a little fringy, but when I began to see
that we have neuroscientists that have linked together – 30 neuroscientists
in the Scientific American just published an editorial saying we need to take another look
at Alzheimer’s disease in relationship to the biome. So let’s kind of think about
how we can feed this biome. What are the nutritional features
that we can do to help our own biome? So, first of all, we have the refined
carbohydrates and the processed foods. You’re probably aware
that of the 600,000 foods that are manufactured in America today,
72 percent of them have added sugar. That did not happen by accident. Sugar is addicting. That processed food is beginning
to actually alter our biome to make us less and less healthy. So obviously,
I teach my patients to just – when they go to a grocery store, just shop around the periphery
where they have real food – well, except for the deli maybe – but real food, don’t go into that sinister middle section
unless you need toilet paper or something. But that’s where
the real food is, is there. Eat real food, because
that’s what our body is set up for. And then eating our vegetables,
and a lot of the fermented vegetables, so your kimchi, and your sauerkraut,
and your kefir, and your yogurt, all of these natural biome foods
should be part of our everyday diet. And when we think about
eating some healthy fats like avocados and walnuts
and these kind of things, that’s very important
to create a healthy biome. And the biome needs protein, so good quality protein
can be a very important feature. Well, I like to think about the lifestyles
in addition to nutrition that could help our biome. And believe it or not,
our gut bugs have a circadian rhythm. They have a night and day rhythm
just like we do. And there are scientists
that are doing research on the circadian rhythms of bacteria. And so when you don’t sleep,
your bugs don’t sleep, and they need sleep. (Laughs) So it’s really important to have that kind
of lifestyle where you get sleep. And believe it or not, exercise also stimulates
a healthy balance of the microbiome. You begin to see a trend here, don’t you? So, then the one that I thought
was just scary, horrible is that our use
of antibiotics in America – 70 percent of all the antibiotics
that are used in America are used to feed the animals from which we get our eggs
and milk and meat and so on – 70 percent. Why do they do that? Because you give antibiotics
to an animal and it gets fat faster, and it goes to market quicker. So 70 percent – ever wonder why
we’re getting more bacteria resistance? And think of all of you – you know,
the first time you get a sniffle – “I’ve got a cold.
Oh, I’ve got to get rid of this. Oh, I better call my doctor and ask
for a Zipac or something,” you know. “Quick, a Zipac!” Every time you treat
your viral infections with an antibiotic, as in bacterial, it changes your biome. So if you do need antibiotics, be sure and follow up
with your probiotics, your kefir, your sauerkraut, your kimchi,
whatever you prefer. You’ve got to repopulate your bowel
if indeed, you have to use antibiotics. So, gut bug cultivation. (Laughs) You know, we should
start a primer on this, you know, there should be something like, “Gut Bugs for Dummies”
or something like that. So first of all, we have to respect them. You know, they’re 90 percent
of who we are – all of our cells; they’re there. And certainly, we want
to take good care of them, we want to make sure that they get
the proper sleep, the proper exercise. And if you have happy bugs,
you’re going ot be a healthy person. Thank you very much. (Applause)

100 Replies to “Microbiome: Gut Bugs and You | Warren Peters | TEDxLaSierraUniversity”

  1. Dear Dr. Thanks for clearing out myths about the Gut Bugs. There is a lot of information out but I don't know which one to believe. Thanks once again.

  2. Yes, this is very useful to all kinds of people with digestive problems. It's absolutely fascinating. Thanks for posting.

  3. and foods can have a narcotic effects i.e. endorphins Scientists stunned to learn that gut bacteria seem to have control over your moods and brain function

  4. Truly an excellent presentation. Too bad man's ego will still not let him see anything with an aloft perception, be it the one long time belief that the world was the center of the universe or even the current belief that the destruction of our microbiome by antibiotics is some how okay, because we can just replenish them with probiotics. They deserve (and I say they, while actually recognizing that they are the major component of us) more respect than our little finger. Just imagine that your surgeon has just severed  your pinkie to remove a ring, but not to worry, because he can just sew it back on.This doctor is certainly way above his colleagues, but the microbiome is not new.  How many doctors do you think are even aware that we now know that plants communicate with us? It has been proven that the RNA of ingested plants exchange information with our own RNA.BTW, if you'd like to check out your microbiome, then go to the organization known as American Gut.

  5. Auto-immune diseases.
    In 1991 I "developed" psoriasis after taking a course of amoxicillin… in 2017 it disappeared after exposure to Indigenous Microorganisms. Whether it was the bacterial, fungal, or airborne, innoculum I prepared–or all three in concert–I do not know. Mine was never as bad as some, and I never considered taking drugs proven linked to cancer and death, so… to shut down part or all of the immune system? Approved for vanity? Truly terrifying side effects–couldn't imagine scarier!
    From a historical context, it would seem that the sky would be where such a blessing may be delivered. Nature can't be patented.
    It is a travesty that we are looking to manipulate genomes, or shut down signalling cascades to achieve a result that was intended by nature to be met by the bacillus/biome we keep sanitizing away. Lactobacillus Rules!

  6. @ 3.18 Its the Abrahamic Religions which have put man at the apex of creation Go to Dharmic religions Hinduism and you will find that all the concepts being discussed were known and practiced by Hindus for thousands of years

  7. I've recently stopped buying food in boxes containers and bottles. I make my own salad dressing with fresh ingredients, Guacamole, etc.

  8. Thank you Doctor for making it so simple for dummies like me to digest and understand complexity of the subject.

  9. Not to mention that antibiotics can damage your mitochondria DNA and act as a neurotoxin on the brain. But you know…little details.

  10. Has anyone heard of a study done on the microbiomes of Asians who do eat a lot of vegetables. I had a lot of Chinese friends in college and they did not like our food at all. Their greatest joy was to eat vegetables and they couldn’t wait to spend every day or so chopping them up with great enjoyment. Of course they were all thin. When I eat like a Chinese or when I specially eat raw vegetables I do feel quite full and quite oblivious to add foods like candies.
    Another thing very related to all this is that trees have a similar thing to our microbiome – also and probably all plants have a gigantic layer of fungus I believe within their root systems that does exactly the same thing that our biome does it feeds them processes things for them and they cannot exist without it also. I have just wondered if anybody noticed the similarity of the two biomes.

  11. Thought it is quite interesting that the bugs need to sleep. Maybe that is why not eating late at night is a good idea.

  12. my grandma always taught me to stock up on yogurt whenever I'm prescribed antibiotics. I never knew why and now I do ! Great talk 🙂

  13. Thank you Mr.Peters! You are right, the bugs need good foods: "Optimum Nutrition is the Medicine of the Future"

  14. Do you still not think Bruce Lipton, PhD is onto something when he asserts that the human genetic model is incomplete? He believes we have at least 100,000 genes. I do too. 🙂

  15. hi, i’m going to be doing a DIY FMT using my fathers stool, my father is taking Bisoprolol fumarate 1-25 mg and Amlodipine 5 mg and i was hoping i could find out if this could make him a bad donor for me to use?

  16. SUGAR is the main culprit that feeds the YEAST !! IT is a slow toxin for all, not necessarily artifical sweetners, even though most are no good either.. PURE stevia does not affect the Glysemic which cause insulin intolerance..

  17. You people do know there is obviously several groups out there. One may be for health and longevity while another is against it. Ill give you some twisted hints to ponder. They tell you eat your fruits and veggies right. Yet they spray them with toxins as they grow. And then they spray them again before they go to the store with something called phages. Phages are FDA approved viruses that when sprayed on foods slow the rotting process, they spray it on most everything even meats and organic foods. This slows rotting caused by bacteria, but these phages which are types of virus infect and kill bacteria, and when an infected dead bacteria dies it releases more of the same phages. And then you eat the fruits and veggies sprayed with phages that kill bacteria. They say its safe, they say it only kills the bad bacteria. But we all know phages or virus and bacteria mutate all the time. Thats why they cant stop the common cold right. Because the phages or virus that cause colds are always mutating. Think about it, what else can I say, google phages sprayed on foods.

  18. So interesting. Will be definitely looking at his suggested foods.

    Amazing how much Warren sounds and looks just like Tim Cook CEO of Apple.

  19. I don't know any doctor here in Canada that give antibiotics for colds virus and flu ever. Honestly when I have been sick I stay home and don't go to the doctor unless I suspect its turned into an infection.

  20. I have UC, is there particular probiotics that are good for this condition. I have been taking SIBO lately as well as L-glutamine.

  21. I think Chinese Medicine is kind of an intuitive way of keeping your Gut Biome healthy. Doctors do the exam by checking your pulse and looking at your tongue, then prescribe you a medicine you drink which is meant to adjust your balance of your body (yin/yang) by introducing or taking away toxins. It kind'a makes sense now that it's mostly about checking your gut biome. BTW my mother had depression and it wasn't until she got on Chinese Medicine that she got markedly better after circling through a cocktail of drugs for a decade. Totally works.

  22. Any way I can get the sources for this talk? I'm doing my graduation seminar on this and it only gets more interesting!!!!

  23. the bugs in my belly are getting drunk right now , lucky bastards cheers fellas 🍻

  24. Good points. However, I cannot eat kimchi because I have IBS and Kimchi has red pepper sauce. Plain kimchee I can eat. I still eat red pepper kimchi on occasion, but it burns.

  25. Beside nutrition, "PERFECT LOVE cast out fear! … Just spend time with her, focusing on loving her, meeting her needs, accepting her "AS IS" unconditionally, set aside specific time few hours a week just to be with her, go with the flow, do whatever she wishes, much like mirroring autistic child for withdrawing into their own world, in whatever form, is a mechanism of coping with FEAR … FEAR of REJECTION, failures, unknown due to traumas, regrets, bad experience in the past, old frustration feeling of neglect by people, themselves and God disappointing failing abandoned them … Be there consistently unconditionally lovingly cherishing accepting them, and the LIGHT WILL SHINE AND OVERCOME DARKNESS THAT HID THEIR MIND SOUL WILL EMOTION, AND THEIR TRUE SELF WILL BREAK FORTH IN FREEDOM OF "BEING" who they are warts and all knowing that you truly love them as is and you've proven trustworthy to always be THERE for them no matter what … Trust me on this works even in those not mentally I'll, well, face it, Alzheimer dementia etc are neurodegenerative chemical Imbalance plague death of select brain cells, call it what you will … Dr HENRY WRIGHT quoted research that backed up EMOTION CREATES CHEMICAL hormones type of bugs colony etc that Affect your well being… As much as importance of nutrition, exercise, rest, it's much more important to well being to have HEALTHY social emotional connection and state of health, inner peace, love, joy 💕💕💕💕💕💕💕💕 … Yes coconut oil ketones help as per Dr Mary Newport treating her hubby but it's as much her LOVE ❤️ and dedication to curing him that heals Hubby's SOUL WOUNDS rooted in FEAR of REJECTION by people, God, life, career, society, etc … Ponder on that 🤔

  26. I don't know why every Ted Talk is so annoying somehow. I guess it's the weird way they're talking every time? They drive me nuts it doesn't matter who the speaker is or what the topic is I cannot stand listening to Ted Talks.

  27. I’ll never touch another antibiotic. I have been so uneducated and the antibiotics and steroids have destroyed me. I have been fighting to rebuild my system for 10 months and it’s terrible. Smh it’s an awful awful thing.

  28. So how did our babies develop a biome before they began swabbing the C-section babies with their mother?

  29. Excellent talk…right on! Have experienced this with my mild form of MS and am healing my gut microbiome now by following these exact suggestions! "Let food be thy medicine, and medicine thy food'…"all disease begins in the gut'"….Hippocrates, the founding father of ancient medicine who also recommended apple cider vinegar drinks! Looks like he knew what he was talking about! More allopathic doctors should have listened to him in medical school when they take the Hippocratic oath to be medical doctors! Thanks for sharing~

  30. I would like to know how destructive is raw honey to our microbiome . How much is to much ? How to eat it . This past winter after a bad flu I noticed a change in my regularly after emptying the shelves of Manuka honey of my local Whole Foods

  31. He may not have a degree, but what he has over some of these experts is that he has experienced Colitis. Those of us know what it feels like suffer from Colitis. I have changed my diet and it has made change to my Health. Also these are the things I found have helped: Diet, Fitness, and Reduce Stress. I find Stress is a big factor and by eliminating or reducing stress has a big factor. These are my experiences and the the results have been good when I reduce my stress and increase my exercise and diet.

  32. My cousin was diagnosed with Anorexia nervosa, took so many treatments, but no relief was seen. One day her friend told her about Planet Ayurveda, whose treatment was going here. She ordered medicines online like Digestion support and all and is still using these medicines. Now she has much relief.

  33. I heard many doctors recommending a whole food plant based diet to obtain a healthy gut microbiome , the more i study about this the more i’m convinced by these recommendations 🌱

  34. Would eating at a reputable (keg) restaurant kill my micro biome in my GIT?
    When I eat out I get gassy bloated and loose stool. The food looked and tasted good. Suspecting MSG ya the least .

  35. i could do an incredible thing to help to understand of the microbiome. some engineering and an Ai could really help map out the best contenders in the microbiome and slowly as we grow our training data learn all of their attributes. it's just like AI Zelda, just on a different video input plain. could even add a 3d telescope to record 150x+ at 120 fps, the idea is it follows the life of each specimen long term and follows the evolution

  36. Do you know and bugs that help break down rice carbs? my western culture has killed my biome and I'm needing some new cultures to help. Hire me, and ill take a crack at it

  37. So, we're just….10 percent of who we are and the rest…is bacteria? So…..how much does THAT influence Everything? Would be interesting to see how this effects those with any type of mental illness.This is super interesting!

  38. He doesn't specify what "quality protein" is….. it's unprocessed plant protein…. so our gut bacteria metabolizes it down to nontoxic components that won't increase risk of inflammation and cancer….. which is what happens when our gut bacteria is fed animal protein…. including dairy…. so skip the yogurt made with dairy milk. There are plant based yogurt options or just take probiotics in capsules.

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