E02 – Early Sign of Neurodegenerative Disease – Minimal Cognitive Impairment [Explainer Video]

E02 – Early Sign of Neurodegenerative Disease – Minimal Cognitive Impairment [Explainer Video]


So, one of the questions that we grapple with at Amprion
is where is the biggest initial impact for our technology? And we think that it’s
probably in the area for patients who suddenly present
for the first time to their family members or their
physician with confusion that it’s not clear whether
it’s just the extreme aspects of normal aging or the earliest signs of some sort of neurodegenerative disease. And that tends to fall
into a class of diseases referred to as MCI, or
Minimal Cognitive Impairment and over time, it’s known that
minimal cognitive impairment, if you observe these patients,
it’s a real mix of outcomes. Approximately a third go on
to dementia, most of which would be Alzheimer’s type
dementia, and what we would expect to find in this group
that go on to dementia, at the time they present with
minimal cognitive impairment is high levels of misfolded
protein, mainly Abeta and Tau. There’s a second group,
another third, that just over at least the next three to
five years, that normalize, they go back, they don’t get
much worse and in many cases, go back to normal cognitive functioning. So what we expect here is
low levels of Abeta and Tau and if we can distinguish
between these two, we can help at a very early time. If there are no misfolded proteins, we believe that there is no likelihood of a neurodegenerative progressive disease over the next five to ten years. There’s another third of
patients that present with MCI that go on to other things. Some of them may stay the same. Others may develop motor so a
certain number of Parkinson’s patients who go on to
have mainly motor symptoms start off at the earliest
time being a little confused and we think we can help there too. There isn’t much known but we
think this might be a group that has maybe more atypical
patterns of misfolded proteins. Maybe a significant number of
these have misfolded Synuclein and we’ll be able to predict
outcomes for them as well.

Leave a Reply

Your email address will not be published. Required fields are marked *